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This study aims to evaluate the long-term effects of gadolinium or gadoteric acid single exposure on kidney gene expression.

May 7, 2026Science LettersOpen Access

Gadolinium and gadoteric acid single exposure – long-term impact on the kidney’s gene expression

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This study aims to evaluate the long-term effects of gadolinium or gadoteric acid single exposure on kidney gene expression.
Male Wistar rats were divided into 3 groups and exposed to a single dose (0.1 mmol/kg) of gadolinium, gadoteric acid, or vehicle control.
Renal tissue was collected 20 weeks after exposure to evaluate gene expression (RNASeq).
Gene Set Enrichment Analysis (GSEA) was performed on identified differentially expressed genes.
The gadolinium group showed up-regulation of genes associated with immune response and xenobiotic metabolism.
The gadoteric acid group also showed distinct gene expression changes, indicating differing impacts on kidney function from gadolinium.
GSEA revealed significant enrichment in differentially expressed genes for gadoteric acid compared to gadolinium.
The results indicate long-term disturbances in gene expression related to immunity and metabolism.

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Single exposure to gadolinium disrupts gene expression in kidneys, suggesting long-term effects on metabolism and injury.

Coimbra et al. (2026) studied this question.

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