Observational study shows reduction in stroke lesion volume with AT2R agonist in aging hypertensive rats, suggesting therapeutic potential.
Motivation: The synergistic effects of hypertension and aging on brain morphology is described and the evolution patterns of cerebral atrophy from spatial and temporal perspectives using Rat stroke model. Goal(s): Using non-invasive MRI techniques, we have investigated changes in the brain of 18-month-old spontaneously hypertensive (SHR) rats following a 30-minute transient middle cerebral artery occlusion (tMCAO) or SHAM for 8 weeks. Approach: Using multi-parametric MRI data to access the treatment efficacy Results: Our results demonstrate that treatment of stroke with Angiotensin type 2 receptor (AT2R) agonist reduced lesion volume compare to non-treated group. Impact: The C21-treatement improve outcome.
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Bosomtwi et al. (2025) studied this question.
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