Key result
Aged stroke-free SHRSP rats show no MRI white matter hyperintensities or deep penetrating vasculopathy.
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Demonstrates an absence of white matter hyperintensities and deep arteriopathy in stroke-free spontaneously hypertensive rats, indicating these lesions are not an obligate feature of hypertension.
Hypertension is associated with cerebral small vessel disease (SVD) and with diffuse white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging (MRI). We tested whether stroke-prone spontaneously hypertensive rats (SHRSP), a model of chronic hypertension, exhibit WMH. Male SHRSP (age 10 months) without stroke symptoms were compared with age-matched male WKY rats. Stroke-prone spontaneously hypertensive rats exhibited no WMH on MRI scans (T2, T2*, diffusion tensor imaging) and no neuropathological lesions. While leptomeningeal arteries exhibited fibrohyaline wall thickening, with decreased smooth muscle actin relative to WKY, deep penetrating arterioles within the caudate nuclei had no vasculopathy. We conclude that WMH are not an obligate feature of stroke-free SHRSP aged up to 10 months.
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Brittain et al. (2013) studied Chronic hypertension and cerebral small vessel disease (preclinical SHRSP rat model). Chronic hypertension (SHRSP model) vs. Age-matched male WKY rats was evaluated on White matter hyperintensities (WMH) on MRI (T2, T2, DTI) and neuropathological lesions. Stroke-free male SHRSP rats aged 10 months exhibited 0% white matter hyperintensities on MRI and no deep penetrating arteriolar vasculopathy compared with WKY rats.
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