Why the study?
Does the development of functional symptoms in stroke-prone spontaneously hypertensive rats correlate with hemodynamic or metabolic alterations in the brain before overt infarction?
Population
Stroke-prone spontaneously hypertensive rats fed a salt-rich diet starting at 6 weeks of age, evaluated at…
Comparison
Development of functional symptoms vs Age-matched symptom-negative SHR-SP
Design
Preclinical
Follow-up
Evaluated at 12 weeks of age
Authors
Loading...
Symptoms may mark early global CBF decline before infarction in SHR-SP; hypothesis-generating for diffuse decompensation in human stroke-prone hypertension.
Does the development of functional symptoms in stroke-prone spontaneously hypertensive rats correlate with hemodynamic or metabolic alterations in the brain before overt infarction?
Genetic abnormalities in stroke-prone spontaneously hypertensive rats are associated with a diffuse vascular process causing global decompensation of blood flow before the onset of focal brain infarction.
Mies et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: