Key result
SHR-SP rats show a ~35% stroke incidence compared to zero in standard SHR.
Why the study?
The mechanisms underlying the higher incidence of stroke in stroke-prone spontaneously hypertensive rats compared with age-matched SHR remain to be fully understood, particularly regarding cerebral artery remodeling and arterial baroreflex function.
Population
28-week-old SHR (n=25) and SHR-SP (n=26) rats
Comparison
Stroke-prone SHR (SHR-SP) vs spontaneously hypertensive rats (SHR)
Design
Comparative observational study with neuroethology assessment and cerebral artery histology
Authors
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Supports SHR-SP as a stroke model in hypertension; leaves open translation to human cerebrovascular risk pending prospective validation.
Absolute Event Rate: 34.62% vs 0%
Yang et al. (2011) studied Hypertension and stroke (n=51). Stroke-prone substrain (SHR-SP) vs. Standard spontaneously hypertensive rats (SHR) was evaluated on Stroke incidence (positive signs). The stroke-prone spontaneously hypertensive rat (SHR-SP) substrain exhibited a 34.62% incidence of stroke signs compared to 0% in standard SHR, alongside greater cerebral artery remodeling.
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