Key result
Stroke-prone spontaneously hypertensive rats exhibited an abnormal circadian blood pressure rhythm shifted towards the resting phase, which was associated with progressive target-organ damage.
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Does not yet support rhythm-based BP management in hypertension; leaves open whether circadian shifts drive human target-organ damage.
Shimamura et al. (1999) studied Hypertension. Stroke-prone spontaneously hypertensive rat strain (SHRSP) vs. WKY and SHR rats was evaluated on Diurnal patterns of blood pressure and target-organ damage. Stroke-prone spontaneously hypertensive rats exhibited an abnormal circadian blood pressure rhythm shifted towards the resting phase, which was associated with progressive target-organ damage.
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