This research shows the association of epicardial adipose tissue and left atrial strain with heart failure, indicating new prognostic tools for patients with HFpEF.
Motivation: The pathogenesis of HFpEF and the risk factors affecting its prognosis remain poorly understood. Goal(s): Exploring the value of EAT and left atrial strain in predicting heart failure and adverse prognosis in patients with heart failure with preserved ejection fraction. Approach: The epicardial adipose tissue (EAT), the three LA phasic strains, as well as the left ventricular longitudinal, radial, and circumferential strains were calculated with CVI42. Results: The three LA strains are indicators for evaluating adverse prognosis in patients with HFpEF. EAT and global longitudinal strain are indicators for predicting heart failure; however, they did not demonstrate an advantage in predicting adverse prognosis. Impact: Our research elucidates that increased EAT thickness in patients with HFpEF suggests o left ventricular dysfunction, while early abnormalities in LA function can serve as a predictor of adverse prognosis.
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Li et al. (2025) studied this question.
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