Evaluates retrospective lipid removal's impact on metabolite concentration estimates, suggesting future studies are needed.
Motivation: Robust and efficient solutions are needed to accurately remove lipid signals for fast 1H-MRSI in the rodent brain while preserving the metabolite signals. Goal(s): Analyze the effects of retrospective lipid suppression on metabolite estimates at 14.1T in the rat brain for 1H-FID-MRSI. Approach: SVD-based lipid suppression was applied for retrospective lipid suppression. Results: Overall, the retrospective lipid suppression is slightly influencing the metabolite concentration estimates in the rat brain for 1H-FID-MRSI at 14.1T. Impact: Our work is evaluating the retrospective lipid suppression on metabolite estimates at 14.1T in the rat brain for 1H-FID-MRSI. When using low lipid contaminated data, an effect on concentration estimates was observed, highlighting the need for future investigations.
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Phan et al. (2025) studied this question.
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