Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in alcohol use disorder

Motivation: Abnormalities in structural or functional connectivity between hemispheres may disrupt functional interaction within the brain. Goal(s): This study allows us to assess the time variability of brain activity and to identify the principal hub links in cerebral hemisphere network distributions. Approach: We analyzed resting state functional magnetic resonance imaging (fMRI) data from the subjects. A sliding window analysis was used to calculate the intracerebral and interbrain dynamic functional connection density (dFCD) of voxel direction. Results: Compared to the HCs, AUD patients exhibited abnormal global, interhemispheric and intrahemispheric dFCD in the caudate, insula, parietal lobe, and occipital lobe. Impact: This study identified the distribution of major central connections at the hemispherical level of abnormal brain networks that can be used as therapeutic targets in AUD patients.