Intrinsic brain functional connectivity patterns in alcohol use disorder

Figures

• 

  Figure 1 Common functional connectivity networks.. Example of spatial representation maps is shown for ten of the major independent components identified at a group level in the entire sample (the AUD and CTRL groups) using ICA. The maps represent z-statistic scores thresholded at z = 2 (range = 0–11).

• 

  Figure 2 Differences in functional connectivity of the default mode network.. (A) The map represents regions with significant differences in functional connectivity between the AUD versus CTRL groups determined using GLM. In this analysis, the cluster-level FDR-corrected threshold was set at P < 0.05 based on Gaussian random field theory. Yellow signifies regions where net connectivity differences between AUD and CTRL were negative values, and Pink signifies regions where net connectivity differences between AUD and CTRL were positive values. (B) The bar graphs represent the average differences in Fisher-transformed correlation values between the AUD and CTRL groups, for clusters identified at the p-FDR threshold of P < 0.05. Error bars represent 90% confidence intervals for the estimates. Abbreviations: AUD, alcohol use disorder group; CTRL, control group; L, left hemisphere; R; right hemisphere.

• 

  Figure 3 Connectivity differences identified based on dynamic ICA.. A cluster of regions was identified showing differences based on dynamic ICA between the AUD and CTRL groups using GLM where cluster-based inference was based on cluster-level p-FDR-corrected threshold of P < 0.05 and using a MVPA omnibus test. The uncorrected region to region connection threshold in this analysis was also set at P < 0.05. Blue (AUD > CTRL) and red (CTRL > AUD) indicate differences in dynamic functional connectivity. The colour bar indicates T-statistics values. Warmer (red-yellow) colours represent decreased dynamic FC in AUD (AUD < CTRL), colder (blue) colours represent increased dynamic FC strength in AUD (AUD > CTRL). Abbreviations: PreCG, precentral gyrus; PostCG, post-central gyrus; SMA, supplementary motor area; MPFC, medial prefrontal cortex; MedFC, medial frontal cortex; SubCalC, subcallosal cortex; PaCiG, paracingulate gyrus; L, left hemisphere; R, right hemisphere.