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September 25, 2023Open Access

Differences in Brain Network Topology Based on Alcohol Use History in Adolescents

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Why the study?

Little is known about how alcohol consumption in adolescence may alter brain function, leading to long-term developmental detriments.

Does hazardous alcohol use alter brain network topology in adolescents compared to no/low alcohol use?

Population

698 youth aged 12-21 years

Comparison

117 hazardous drinkers vs 581 no/low drinkers

Authors

HKHaley A. KirseMBMohsen BahramiRLRobert G. Lyday

Discussion

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Overview

Adolescent hazardous drinking links to altered brain network topology; leaves open causality and clinical relevance pending longitudinal data.

Structured PICO

Does hazardous alcohol use alter brain network topology in adolescents compared to no/low alcohol use?

P
Population
698 youth (12-21 years, 117 hazardous drinkers and 581 no/low drinkers) from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA)
I
Intervention
Hazardous alcohol use
C
Comparator
No/low alcohol use
O
Outcome
Differences in brain network topology in eight pre-defined brain networks and whole-brain connectivity using resting state functional magnetic resonance imagingsurrogate

Hazardous alcohol use in adolescents is associated with aberrant connectivity in specific brain networks compared to no/low alcohol use.

Cite This Study

Kirse et al. (2023) studied this question.

synapsesocial.com/papers/6a8a4886bc8a49327d721d53https://doi.org/10.20944/preprints202309.1626.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developmental changes in functional brain networks from birth through adolescence2018 · 57 citations
  2. 2Learning and Memory in Adolescent Moderate, Binge, and Extreme‐Binge Drinkers2016 · 61 citations
  3. 3Disruptions in Functional Network Connectivity During Alcohol Intoxicated Driving2009 · 35 citations
  4. 4Dynamic connectivity patterns of resting-state brain functional networks in healthy individuals after acute alcohol intake2022 · 10 citations
  5. 5The role of the orbitofrontal cortex and the nucleus accumbens for craving in alcohol use disorder2021 · 62 citations