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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Structural-functional coupling subtypes of major depressive disorder and their associations with genetic and neurotransmitter profiles

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Authors

HGHuaijin GaoRQRui QianYGY. G.

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Overview

Analysis reveals two MDD subtypes linked to neurophysiology and molecular differences, suggesting tailored treatments.

Key Points

  • Two distinct subtypes of major depressive disorder were identified based on structural-functional coupling patterns, revealing important neurophysiological differences.
  • The study found that the identified subtypes exhibited unique clinical symptoms, highlighting the heterogeneity in major depressive disorder.
  • Resting-state fMRI and T1-weighted imaging were used to calculate structural-functional coupling, correlating with genetic and neurotransmitter profiles.
  • These findings point to potential personalized treatment strategies for major depressive disorder, enhancing diagnostic and therapeutic approaches.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68d45b0b31b076d99fa5d12ehttps://doi.org/10.58530/2025/1125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional Connectivity Subtypes in Major Depressive Disorder: Insights Into Connection Patterns and Neurobiological Mechanisms2025
  2. 2Resolving Heterogeneity in Major Depression: Overcoupling and Undercoupling Subtypes Exhibit Differential Treatment Response and Molecular Pathways2025
  3. 3Functional connectivity subtypes of MDD and their associations with gene expression profile, neurotransmitter, and cognition2024
  4. 4Heterogeneity of brain functional connectivity, transcriptome, and neurotransmitter profiles in major depressive disorder2025 · 1 citations
  5. 5Elucidating genetic and molecular basis of altered higher-order brain structure-function coupling in major depressive disorder2024 · 13 citations