Retrospective analysis shows a weak inverse correlation between PSMA-PET/CT SUV and ADC in prostate cancer, implying the impact of androgen deprivation therapy on imaging.
Motivation: Prostate cancer (PC) imaging utilizes PSMA-PET/CT and DWI for assessing tumor characteristics and treatment response, which should be useful in MR-guided radiotherapy (MRgRT). Goal(s): Investigate the correlation between PSMA-PET/CT SUVmax and ADC in PC patients undergoing MRgRT to understand their complementary roles. Approach: Retrospectively analyzed 17 PC patients who underwent pre-MRgRT PSMA-PET/CT and MR-simulation. Pearson's correlation between SUVmax and ADC was evaluated. Results: An weak inverse correlation between SUVmax and ADC (r=-0.30, p=0.08) was found in 34 lesions. The lack of significance may be primarily due to the androgen deprivation therapy administration between PSMA-PET/CT and MRI, affecting ADC but not SUVmax. Impact: This study underscores the intricate relationship between PSMA-PET/CT SUV and DWI-ADC in prostate MRgRT, significantly affected by the timing of androgen deprivation therapy administration, which may influence the scheduling and logistics of MRgRT imaging.
No takes yet. Share an insight, caveat, or question.
Yuan et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: