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Custom mold enables precise tissue sampling in prostate cancer, suggesting improved biopsy techniques.
Motivation: Currently, no reliable way exists to sample fresh, viable prostate cancer tissue in a clinically localized setting. This hampers basic science research on prostate cancer cell lines. Goal(s): Creation of a 3D mold with needle guides from existing prostate boundary & lesion segmentations to enable harvesting cancer tissue from an explanted prostate without impacting the clinical pathology workflow. Approach: A 3D mold with needle guides was created in Solidworks and then 3D printed. This was used to guide extraction of live cancer tissue via a standard biopsy gun. Results: In 10/10 patients, biopsies performed with the 3D-printed mold yielded prostate tissue with cancer. Impact: Our 3D mold platform enables harvesting live cancer from a prostate that has biopsy-proven, positive MR-targeted lesions and resulted in excellent cancer yield across 10 patients. The design is intuitive for clinicians and does not interfere with clinical pathology workflow.
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Du et al. (2025) studied this question.
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