Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Multi-parametric quantitative MRI of the lower limb muscles in a longitudinal study of limb-girdle muscular dystrophy R9

View Full Paper
Ask AI
Bookmark
Share

Authors

SRSusanne RauhPBPierre-Yves BaudinTSTanya Stojkovic

Discussion

Loading...

Member takes

Overview

Longitudinal study reveals significant differences in MRI parameters between LGMD-R9 and controls, suggesting qMRI may indicate disease progression.

Key Points

  • qMRI parameters showed significant differences between LGMD-R9 patients and healthy controls, indicating potential as biomarkers.
  • Fat fraction, water-T2, water-T1, and pH demonstrated significant correlation with LGMD-R9 progression, suggesting predictive capabilities.
  • Longitudinal assessments after 1 and 2 years highlighted changes in water-T2 and water-T1 related to increases in fat fraction.
  • These findings support the use of qMRI in identifying biomarkers for clinical trials targeting LGMD-R9.

Cite This Study

Rauh et al. (2025) studied this question.

synapsesocial.com/papers/68d45b1b31b076d99fa5d5dbhttps://doi.org/10.58530/2025/0563
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-parametric quantitative MRI of the lower limb muscles in a longitudinal study of limb-girdle muscular dystrophy R92025 · 2 citations
  2. 2Quantitative muscle magnetic resonance imaging in limb‐girdle muscular dystrophy type R1 (LGMDR1): A prospective longitudinal cohort study2024 · 1 citations
  3. 3Longitudinal Assessment of Muscle Involvement in Late‐Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study2026
  4. 4Quantitative Magnetic Resonance Imaging in Limb-Girdle Muscular Dystrophy 2I: A Multinational Cross-Sectional Study2014 · 97 citations
  5. 5Natural history of limb girdle muscular dystrophy R9 over 6 years: searching for trial endpoints2019 · 40 citations