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This is a Systematic Review study.

September 17, 2025LifeOpen Access

Indications and Mechanisms of Action of the Main Treatment Modalities for Non-Melanoma Skin Cancer

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This review details the applications of surgical therapy and immunotherapy in non-melanoma skin cancer, highlighting their mechanisms and efficacy.

Surgical therapy demonstrates high cure rates for non-melanoma skin cancer, with Mohs micrographic surgery achieving up to 99% cure in some cases.
Imiquimod, an immune response modifier, enhances anti-tumor activity by triggering immune cell responses and producing pro-inflammatory cytokines.
Radiation therapy effectively induces DNA damage in cancer cells, contributing to tumor cell death via reactive oxygen species generation.
Cemiplimab has shown efficacy in the treatment of locally advanced squamous cell carcinoma, significantly reducing tumor size and recurrence risk.

Chedid et al. (2025) studied this question.

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This review details the applications of surgical therapy and immunotherapy in non-melanoma skin cancer, highlighting their mechanisms and efficacy.