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This is a Literature Review study.

September 10, 2025

Non-Excisional Treatment of Multiple Cutaneous Squamous Cell Carcinomas: A Narrative Review of Emerging Modalities and Clinical Outcomes

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Narrative review examines non-excisional therapies for cSCC, highlighting immunotherapy and PDT effects.

Cemiplimab demonstrated up to 100% disease clearance in immunocompromised cSCC patients, showcasing its efficacy.
Photodynamic therapy proved beneficial for pediatric patients with genetic conditions related to cSCC.
EGFR inhibitors showed modest efficacy in unresectable cSCC patients while posing greater toxicity risks.
The review noted mild adverse effects across therapies, emphasizing the need for further studies despite efficacy.

Neidig et al. (2025) studied this question.

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