What question did this study set out to answer?

This review aims to summarize the management of advanced cutaneous squamous cell carcinoma (cSCC) in high-risk populations.

November 17, 2025CancersOpen Access

Immune Checkpoint Blockade Therapy for Advanced Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients, Transplant Recipients, and Individuals with Hereditary Syndromes: A Narrative Review

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Narrative review highlights efficacy and safety of immune checkpoint blockade in advanced cSCC in challenging patients.

This review aims to summarize the management of advanced cutaneous squamous cell carcinoma (cSCC) in high-risk populations.
Literature review of trial data and real-world evidence
Evaluation of treatment strategies in immunosuppressed patients
Analysis of guidelines addressing care for difficult-to-treat groups
Immune checkpoint inhibitors demonstrate efficacy in advanced cSCC management
Challenging populations face unique risks and limited evidence for treatment
High tumor mutational burden correlates with positive therapeutic responses

Pabianek et al. (2025) studied this question.

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