Unveiling Cadmium-Induced Cardiotoxicity: Mechanisms, Challenges, and Future Perspectives: A Narrative Review

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Narrative review uncovers mechanisms and therapeutic targets for cadmium-induced cardiotoxicity, indicating potential preventive strategies.

Cadmium exposure leads to significant cardiotoxicity through oxidative stress and inflammation, impairing cardiac function.
Key mechanisms include endothelial dysfunction, calcium signaling disruption, and cardiomyocyte damage, highlighting critical pathways.
Current therapies focus on cadmium removal but do not address lingering cardiovascular damage from exposure, which may require novel strategies.
Future interventions should target platelet and leukocyte activation, as well as endothelial cell function, to improve outcomes.

Pouladzadeh et al. (2025) studied this question.

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View Full Paper

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Authors

Narrative review uncovers mechanisms and therapeutic targets for cadmium-induced cardiotoxicity, indicating potential preventive strategies.

Cadmium exposure leads to significant cardiotoxicity through oxidative stress and inflammation, impairing cardiac function.
Key mechanisms include endothelial dysfunction, calcium signaling disruption, and cardiomyocyte damage, highlighting critical pathways.
Current therapies focus on cadmium removal but do not address lingering cardiovascular damage from exposure, which may require novel strategies.
Future interventions should target platelet and leukocyte activation, as well as endothelial cell function, to improve outcomes.

Pouladzadeh et al. (2025) studied this question.

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