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September 17, 2025Open Access

TET2 loss impairs MPLA-induced innate immune memory during infection and disrupts hematopoiesis via RIPK1 in mice

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Authors

AJAlyssa JarabekXDXenia DavisMOMary Oliver

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Overview

Observational analysis shows TET2 loss impairs innate immune memory and alters hematopoiesis, suggesting inflammation's role in disease progression.

Key Points

  • TET2 loss impairs the immune response to infection by P. aeruginosa, impacting pathogen clearance and innate immune memory.
  • MPLA pretreatment partially restores the infection response in TET2-deficient mice, indicating potential therapeutic effects on innate immunity.
  • Hematopoiesis is skewed towards myeloid lineages in TET2-deficient mice post-infection, resembling myelodysplastic syndrome-like conditions.
  • Inhibition of RIPK1 in TET2-deficient mice mitigates adverse hematopoietic changes, highlighting a pathway that may influence disease outcomes.

Cite This Study

Jarabek et al. (2025) studied this question.

synapsesocial.com/papers/68d4604731b076d99fa5f795https://doi.org/10.1101/2025.09.08.674943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of innate immune memory on MDS progression by TET2-driven inflammation2025
  2. 2TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem Cells through Upregulation of Thrombopoietin Receptor Signaling2024
  3. 3TET2 as an epigenetic signaling hub: interactome networks, metabolic control and therapeutic vulnerabilities in hematologic malignancies2026
  4. 4TET2 loss triggers ssDNA gap accumulation and heightened PARP inhibitor sensitivity2026
  5. 5Perturbation of iNKT differentiation during clonal hematopoiesis from rewiring of inflammation and lipid presentation2025