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December 8, 2025BloodOpen Access

Impact of innate immune memory on MDS progression by TET2-driven inflammation

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Authors

XDXenia DavisSZSandra S. Zinkel

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Overview

Infection with Pseudomonas aeruginosa worsens inflammation in MDS, indicating innate immune memory's role in disease progression.

Key Points

  • To explore how innate immune memory and TET2 deficiency affect MDS progression and infection responses.
  • Utilized vavTet2fl/fl and vavTet2fl/flRipk1D138N/+ mouse models.
  • Used Pseudomonas aeruginosa sepsis model to evaluate infection response.
  • Administered MPLA to evaluate effects on immune response and hematopoiesis.
  • Analyzed immune cell differentiation and responses using spectral flow cytometry.
  • vavTet2fl/fl mice exhibited impaired infection responses compared to WT.
  • MPLA did not fully protect TET2-deficient mice from infection.
  • Reduced ROS production and phagocytosis were noted in TET2-deficient groups.
  • MPLA with infection impacted myeloid-biased differentiation in TET2-deficient models.

Cite This Study

Davis et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d243https://doi.org/10.1182/blood-2025-1400
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TET2 loss impairs MPLA-induced innate immune memory during infection and disrupts hematopoiesis via RIPK1 in mice2025
  2. 2Mavs mediates inflammatory memory in hematopoietic stem cells and promotes ineffective hematopoiesis2025
  3. 3Accelerated adverse cardiac remodeling in a model of TET2 mutation-driven clonal hematopoiesis is ameliorated by IFNa treatment by modulating the monocyte response2025
  4. 4The bromodomain and extra-terminal domain protein BRD4 promotes both self renewal and inflammation in TET2 mutated clonal hematopoiesis2025
  5. 5Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis2026 · 2 citations