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December 8, 2025Blood

Mavs mediates inflammatory memory in hematopoietic stem cells and promotes ineffective hematopoiesis

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Authors

JXJuying XuCincinnati Children's Hospital Medical CenterMJMichael B. JordanCincinnati Children's Hospital Medical CenterMFMarie–Dominique FilippiCincinnati Children's Hospital Medical Center

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Overview

Chronic inflammation reduces hematopoiesis in hematopoietic stem cells, indicating MAVS may be a therapeutic target in myelodysplastic syndromes.

Key Points

  • This research investigates the role of MAVS in inflammatory memory and hematopoiesis in hematopoietic stem cells (HSCs).
  • Identified MAVS as a mediator of dsRNA-induced HSC immune memory
  • Used polyinosinic-polycytidylic acid exposure to model inflammation
  • Conducted ATAC-seq and RNA-seq to analyze transcriptional changes
  • Performed single-cell RNA-seq to assess HSC heterogeneity
  • Studied effects of MAVS deletion in a mouse model of MDS.
  • MAVS mediates immune memory in HSCs following inflammatory challenges
  • MAVS deficiency prevented HSC functional decline under inflammation
  • Inflammatory conditions resulted in metabolic reprogramming and increased caspase-1 activation
  • Human MDS patients exhibited similar MAVS-related mitochondrial changes
  • MAVS deletion reversed dysplastic features in vivo.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e36bhttps://doi.org/10.1182/blood-2025-974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of innate immune memory on MDS progression by TET2-driven inflammation2025
  2. 2Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells2024 · 24 citations
  3. 3Mitochondrial RNA as a broad-spectrum DAMP coordinates antiviral and damage-related immune clearance and confers therapeutic potential2026
  4. 4Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus2016 · 182 citations
  5. 5Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy2026