September 17, 2025Open Access

GABAergic ventrolateral preoptic projection to dorsomedial hypothalamus recapitulates post-ischemic neuroprotection by hypothermia

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Authors

PDPelin DilsizIstanbul Medipol University AOAlp OzpinarIstanbul Medipol University BBBuse BalabanUniversity of Health Science

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Implication

This study shows that the GABAergic projection from the vlPOA to the DMH modulates hypothermia, suggesting a new target for neuroprotective therapies.

Key Points

Inhibition of GABAergic DMHVGAT neurons drives hypothermia and decreases ischemic injury.
Optogenetic activation of GABAergic vlPOAVGAT neurons induces hypothermia, similar to the effects seen after inhibition.
GABAergic pathways in the hypothalamus play a crucial role in regulating temperature responses and neuroprotection.
Modulating temperature responses via this GABAergic pathway may avoid side effects of traditional cooling methods.

Cite This Study

Dilsiz et al. (2025) studied this question.

synapsesocial.com/papers/68d4604731b076d99fa5f897 https://doi.org/10.21203/rs.3.rs-5941128/v1

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Implication

This study shows that the GABAergic projection from the vlPOA to the DMH modulates hypothermia, suggesting a new target for neuroprotective therapies.

GABAergic ventrolateral preoptic projection to dorsomedial hypothalamus recapitulates post-ischemic neuroprotection by hypothermia

Discussion

Member takes

Implication

Key Points

Cite This Study

GABAergic ventrolateral preoptic projection to dorsomedial hypothalamus recapitulates post-ischemic neuroprotection by hypothermia

Discussion

Member takes

Implication

Key Points

Cite This Study

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