Figure 2 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895

In vitro transport and transport inhibition by TL-895. Competitive counterflow of [³H]-EβG efflux in the presence or absence of TL-895 or unlabeled EβG in HEK293 cells overexpressing (A) OATP1B1 or (B) OATP1B3. Data represent mean values (bars) and SD (error bars) representative of four independent experiments performed in triplicate. Concentration-dependent inhibition of 8-FcA transport by TL-895 in HEK293 cells overexpressing (C) OATP1B1 or (D) OATP1B3. Data represent the mean values (symbols) and SD (error bars) of two independent experiments performed in triplicate. A two-way ANOVA was used to compare the main effects of concentration and treatment group on normalized intracellular radioactivity. **, P < 0.01 and ****, P < 0.0001.