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September 17, 2025Frontiers in OncologyOpen Access

Editorial: Refractory and relapsed hemophagocytic lymphohistiocytosis in pediatric population: targeted therapy

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Authors

MBMădălina BotaIuliu Hațieganu University of Medicine and PharmacySAS ̧ ener AkyolIstanbul Medeniyet University

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Implication

Editorial explores challenges in managing refractory hemophagocytic lymphohistiocytosis in children, highlighting targeted therapy's potential.

Key Points

  • Targeted therapies can improve outcomes in refractory hemophagocytic lymphohistiocytosis, aiming for durable remissions.
  • A cohort study of 52 pediatric patients showed a high mortality rate of 30.8% despite aggressive treatment.
  • Molecular diagnostics play a vital role in understanding underlying causes and tailoring treatment plans for HLH.
  • Future research should focus on integrating novel agents and enhancing collaborative care among specialists.

Cite This Study

Bota et al. (2025) studied this question.

synapsesocial.com/papers/68d4605131b076d99fa5fb91https://doi.org/10.3389/fonc.2025.1691878
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel perspectives on the rare hemophagocytic lymphohistiocytosis: insights from a multi-center retrospective cohort2026
  2. 2P002 Clinical recognition, treatment and outcomes of HLH, a 15-year experience through the acute medical take2026
  3. 3Encouraging Outcomes in Pediatric Malignancy‐Associated Hemophagocytic Lymphohistiocytosis: Results From the Italian HLH Registry2026
  4. 4Overcoming Diagnostic Challenges: A Rare Presentation of Primary Hemophagocytic Lymphohistiocytosis (HLH) in a Young Female and the Importance of Timely Recognition2024
  5. 5Targeting the cytokine storm: new therapies in the treatment of pediatric hemophagocytic lymphohistiocytosis2026 · 1 citations