September 17, 2025Frontiers in OncologyOpen Access

Single-cell RNA profiling of colorectal granular-type laterally spreading tumor uncovers progression trajectory toward carcinoma and transcriptional signatures favoring lateral morphogenesis

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Granular-type LSTs show enhanced immunogenicity and adhesion interactions, indicating higher heterogeneity compared to adenomas.
High differentiation in LST-Gs includes metaplastic cells and upregulated chaperones, reflecting a hostile tumor microenvironment.
Single-cell RNA sequencing highlights the transcriptional differences between LST-Gs, protruded-type adenomas, and normal tissues.
The Arp2/3 complex upregulation in LST-Gs suggests similarities in cell migration with normal epithelium, indicating a progression axis.

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This study examines transcriptional features of granular-type LSTs and their implications for colorectal carcinoma progression.

Gong et al. (2025) studied this question.

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