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August 8, 2011Endoscopy

The Cooperative Italian FLIN Study Group: prevalence and clinico-pathological features of colorectal laterally spreading tumors

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To assess the prevalence and clinico-pathological features of colorectal laterally spreading tumors (LSTs) in a large cohort undergoing total colonoscopy.
Subgroup analysis of a multicenter cross-sectional observational study across 80 centers in Italy.
Analyzed data from 27,400 total colonoscopies, evaluating patients with detected precancerous lesions.
LSTs were identified in 254 of 5,609 patients with precancerous lesions (4.5%, 95% CI 3.5–6.2), with granular-type LSTs (G-LSTs) comprising 83.1% (211/254) and 60.6% (154/254) located in the proximal colon.
Neoplasia was confirmed in 93.4% of evaluated lesions (225/242), including 143 low-grade adenomas, 76 high-grade adenomas, and 6 submucosal cancers (5 in G-LSTs, 1 in nongranular LSTs).
Risk of advanced histology was not significantly increased in G-LST vs. NG-LST (OR 1.55, 95% CI 0.73–3.27), but was significantly elevated in lesions with large nodules (OR 3.09, 95% CI 1.05–9.04; P = 0.041) or a depressed surface (OR 4.27, 95% CI 1.24–14.61; P = 0.021).

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Implication

Cross-sectional study finds laterally spreading tumors in 4.5% of precancerous colorectal cases, indicating high-risk morphological features require careful endoscopic assessment.

Cite This Study

Rotondano et al. (2011) studied this question.

synapsesocial.com/papers/6a81c5e55fe02a08f3d82d0f https://doi.org/10.1055/s-0030-1256639

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Implication

Cross-sectional study finds laterally spreading tumors in 4.5% of precancerous colorectal cases, indicating high-risk morphological features require careful endoscopic assessment.

The Cooperative Italian FLIN Study Group: prevalence and clinico-pathological features of colorectal laterally spreading tumors

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Discussion

Implication

Cite This Study

The Cooperative Italian FLIN Study Group: prevalence and clinico-pathological features of colorectal laterally spreading tumors

Key Points

Discussion

Implication

Cite This Study

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