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Aspirin 162 mg vs 81 mg for Preeclampsia Prophylaxis in High-Risk Obese Individuals: A Comparative Effectiveness Open-label Randomized Trial (ASPREO)

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Both aspirin dosages demonstrated effectiveness in preventing preeclampsia, indicating potential for broader application.
The trial involved high-risk obese pregnant individuals, providing insights into dosage optimization in this vulnerable population.
Open-label randomized trial methodology enhances reliability in comparing the two aspirin dosages for preeclampsia prophylaxis.
Findings may influence clinical guidelines on aspirin use in pregnant individuals, highlighting the importance of tailored dosing.

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Open-label randomized trial compares aspirin 162 mg and 81 mg for preventing preeclampsia in obese individuals, suggesting both may be effective.

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Amro et al. (2025) studied this question.

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Open-label randomized trial compares aspirin 162 mg and 81 mg for preventing preeclampsia in obese individuals, suggesting both may be effective.