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September 16, 2025Dicle Medical Journal / Dicle Tip DergisiOpen Access

The Protective Effects of Receptor-Interactive Protein Kinase-3 Inhibitor - Dabrafenib on Cisplatin Induced Nephrotoxicity

Mehmet Küçüköner Zeynep Erdoğmuş Özgen Fesih Aktar Ulaş Alabalık Meryem Şeyda Kaya Levent Erdinç İlker Kelle Meral Erdinç

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Key Points

Dabrafenib significantly reduces markers of nephrotoxicity in rats treated with cisplatin after 7 days of administration.
MDA levels rose notably in kidney tissues of the cisplatin group compared to controls, indicating oxidative stress.
Western-blot analyses confirmed changes in RIP1, RIP3, and MLKL protein expressions associated with nephrotoxic damage.
Results highlight the protective role of dabrafenib as a potential therapy against cisplatin-induced kidney injury.

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Implication

Experimental study shows dabrafenib reduces necroptosis in kidneys of rats treated with cisplatin, suggesting potential therapeutic benefits.

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Cite This Study

Küçüköner et al. (2025) studied this question.

synapsesocial.com/papers/68d4605931b076d99fa600d3 https://doi.org/10.5798/dicletip.1785013

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