Protocol for Investigating Periglomerular Afferent Innervation in Mouse Renal Cortex v1

Q: What type of study is this?

This is a Pre-Registered Trial study.

Roman Tyshynsky; Lucy Vulchanova; John W. Osborn

doi:10.17504/protocols.io.81wgbwz51gpk/v1

August 25, 2025

Protocol for Investigating Periglomerular Afferent Innervation in Mouse Renal Cortex v1

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Key Points

The protocol elucidates the anatomical relationship between renal glomeruli and afferent axons, highlighting their potential mechanosensory role.
Focused on afferent axons identified by TRPV1 lineage and CGRP immunolabeling, the study aims to clarify their function.
By investigating the kidney's periglomerular region, this study seeks insights into glomerular pressure monitoring mechanisms.
These findings could advance understanding of renal sensory mechanisms, with implications for kidney function and disorders.

Implication

This protocol investigates renal glomeruli and afferent axons using TRPV1 and CGRP labeling, suggesting a role in pressure monitoring.

Abstract

This protocol aims to investigate the anatomical relationship between renal glomeruli and afferent axons in the mouse kidney, focusing on those identified by TRPV1 lineage and CGRP immunolabeling. The study seeks to elucidate the potential mechanosensory role of periglomerular afferent axons in monitoring glomerular pressure.

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Cite This Study

Tyshynsky et al. (2025) studied this question.

synapsesocial.com/papers/68d4606031b076d99fa60364 https://doi.org/10.17504/protocols.io.81wgbwz51gpk/v1

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Protocol for Investigating Periglomerular Afferent Innervation in Mouse Renal Cortex v1

Key Points

Implication

Abstract

Discussion

Cite This Study

Protocol for Investigating Periglomerular Afferent Innervation in Mouse Renal Cortex v1

Key Points

Implication

Abstract

Discussion

Cite This Study

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