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September 18, 2025Archives of Medical ResearchOpen Access

Regulation of Intestinal Permeability in Health and Disease: Possible Therapeutic Applications

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Increased intestinal permeability is linked to various diseases, including inflammatory bowel diseases and obesity.
Key mechanisms include the zonulin pathway, transcytosis, and dysbiosis, leading to the entry of unwanted substances.
Therapies are being developed to decrease intestinal permeability, potentially improving disease outcomes.
The inflammatory response from translocated microorganisms may contribute to conditions like depression and schizophrenia.

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Review highlights mechanisms impacting intestinal permeability and associated diseases, suggesting potential treatments.

Güemes-González et al. (2025) studied this question.

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