Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 18, 2025Open Access

Different kinetics of humoral response against individual antigens in the ovine model of Toxoplasma gondii infection and its pathological association

View Full Paper
Ask AI
Bookmark
Share

Authors

PFPaula M. FormigoIGIgnacio GualGCGermán Cantón

Discussion

Loading...

Member takes

Overview

Analysis of humoral response against recombinant antigens reveals distinct kinetics in sheep, indicating diagnostic potential and pathological associations.

Key Points

  • Early IgG responses to rGra4Gra7 and rGra8 correlate with acute infections, suggesting valuable diagnostic markers.
  • Anti-rBCLA, rRop2, and rCST9 IgG responses indicate chronic phases and correlate with cyst burden, demonstrating their significance in pathology.
  • The study utilized IgG-ELISA and histopathological analyses to evaluate the immune response and tissue damage related to toxoplasmosis.
  • Findings emphasize the importance of specific antibody kinetics for diagnosing and understanding ovine toxoplasmosis, with potential implications for disease management.

Cite This Study

Formigo et al. (2025) studied this question.

synapsesocial.com/papers/68d461b631b076d99fa608d6https://doi.org/10.1101/2025.09.15.676282
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Acute Immune Response in Sheep Following Immunization with Toxoplasma gondii Tachyzoites or Parasite-Derived Glycoconjugates2025
  2. 2Vaccination with live-attenuated Toxoplasma gondii mutants RHΔtkl1 and PruΔpp2a-c induces protective immunity in sheep2026
  3. 3Comparison of Direct and Indirect Detection of Toxoplasma gondii in Ovine Using Real-Time PCR, Serological and Histological Techniques2024 · 1 citations
  4. 4A combination of GRA3, GRA6 and GRA7 peptides offer a useful tool for serotyping type II and III Toxoplasma gondii infections in sheep and pigs2024 · 3 citations
  5. 5The Development of Toxoplasma gondii Recombinant Trivalent Chimeric Proteins as an Alternative to Toxoplasma Lysate Antigen (TLA) in Enzyme-Linked Immunosorbent Assay (ELISA) for the Detection of Immunoglobulin G (IgG) in Small Ruminants2024 · 12 citations