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September 28, 2025Veterinary SciencesOpen Access

The Acute Immune Response in Sheep Following Immunization with Toxoplasma gondii Tachyzoites or Parasite-Derived Glycoconjugates

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Authors

PMPatrícia Oliveira Meira-SantosGPGabriela Cruz PiedadeMGMaria Tereza B. Guedes

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Overview

Experimental evaluation shows immune response to tachyzoites and glycoconjugates in sheep, indicating potential vaccine applications.

Key Points

  • Infected sheep displayed specific IgM antibodies to lysate and glycoconjugate antigens from day 4.
  • CD8+ T cells increased significantly, while MHC class II+ cells decreased on day 60 post-infection.
  • Experimental groups included those receiving saline, tachyzoites, or glycoconjugates with an adjuvant.
  • Findings suggest the need for improved diagnostic tests and vaccine strategies against toxoplasmosis.

Cite This Study

Meira-Santos et al. (2025) studied this question.

synapsesocial.com/papers/68d913a34ddcf71ba560b91fhttps://doi.org/10.3390/vetsci12100928
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Different kinetics of humoral response against individual antigens in the ovine model of Toxoplasma gondii infection and its pathological association2025
  2. 2Vaccination with live-attenuated Toxoplasma gondii mutants RHΔtkl1 and PruΔpp2a-c induces protective immunity in sheep2026
  3. 3Vaccination of sheep with a live incomplete strain (S48) of Toxoplasma gondii and their immunity to challenge when pregnant1991 · 201 citations
  4. 4A safe and efficacious inactivated vaccine aids prevent reproductive failure associated with congenital toxoplasmosis in ovine2026 · 2 citations
  5. 5Comparison of Direct and Indirect Detection of Toxoplasma gondii in Ovine Using Real-Time PCR, Serological and Histological Techniques2024 · 2 citations