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September 18, 2025Open Access

Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence for Hypoconnectivity and Reduced State Transitions

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Authors

PSParsa SeyedzadehUniversity of Sussex SHS. HosseiniUniversity of Tehran

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Implication

Observational analysis reveals hypoconnectivity and impaired state transitions in individuals with major depressive disorder, indicating network dysfunction.

Key Points

Patients with major depressive disorder showed significantly increased time in hypoconnected states, and displayed diminished neural flexibility compared to controls.
The analysis identified three recurring states of dynamic functional connectivity within the frontoparietal network, revealing the complexity of network interactions in depression.
The methodology employed was resting-state fMRI analysis using a sliding-window approach and k-means clustering to assess dynamic connectivity patterns in a large sample.
These findings highlight the potential of dynamic functional connectivity to provide insights into cognitive inflexibility associated with major depressive disorder.

Cite This Study

Seyedzadeh et al. (2025) studied this question.

synapsesocial.com/papers/68d461bc31b076d99fa60948 https://doi.org/10.1101/2025.09.17.676759

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Implication

Observational analysis reveals hypoconnectivity and impaired state transitions in individuals with major depressive disorder, indicating network dysfunction.

Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence for Hypoconnectivity and Reduced State Transitions

Discussion

Member takes

Implication

Key Points

Cite This Study

Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence for Hypoconnectivity and Reduced State Transitions

Discussion

Member takes

Implication

Key Points

Cite This Study

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