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This research aims to investigate the connectivity changes in brain networks associated with major depressive disorder in adolescents.

June 29, 2026BMC PsychiatryOpen Access

Dysregulated connectivity configuration of functional network model in first-episode, treatment-naive adolescents with major depressive disorder

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This research aims to investigate the connectivity changes in brain networks associated with major depressive disorder in adolescents.
29 first-episode, treatment-naïve adolescents with MDD and 29 healthy controls were recruited.
Resting-state fMRI data were analyzed using group independent component analysis and sliding-window clustering.
Correlation analyses assessed the relationship between connectivity metrics and clinical severity measured by HAMD-17.
Adolescents with MDD showed significantly reduced connectivity in the DMN, SN, and CEN compared to healthy controls.
Reduced frequency of state transitions and longer dwell times in high-connectivity states were observed in the MDD group.
Weaker intra-DMN and intra-DAN connectivity were negatively correlated with HAMD-17 scores, indicating greater symptom severity.

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Randomized trial shows altered brain connectivity in adolescents with major depressive disorder, suggesting unique developmental factors.

Zhang et al. (2026) studied this question.

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