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September 18, 2025Open Access

Interrogation of retinal lipofuscin by fluorescence lifetime imaging microscopy

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Authors

ВАВ. С. АндреевMYM. A. YakovlevaAKAlexey A. Kostyukov

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Overview

Preclinical method evaluates lipofuscin in retinal pigment epithelium, suggesting early diagnostics for degeneration.

Key Points

  • The study identifies key fluorescence parameters for diagnosing age-related macular degeneration.
  • Crucial metrics include the distribution of long and short fluorescence lifetime components, indicating normal versus pathological states.
  • An advanced imaging system combines superconducting single-photon detectors with time-correlated single-photon counting.
  • These insights may enable timely interventions for patients at risk for retinal degeneration.

Cite This Study

Андреев et al. (2025) studied this question.

synapsesocial.com/papers/68d461c231b076d99fa60da3https://doi.org/10.1101/2025.09.12.675809
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  1. 1Time-Resolved Autofluorescence Imaging of Human Donor Retina Tissue from Donors with Significant Extramacular Drusen2012 · 61 citations
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  3. 3Patterns of Fundus Autofluorescence Lifetimes In Eyes of Individuals With Nonexudative Age-Related Macular Degeneration2018 · 76 citations
  4. 4Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells2023 · 20 citations
  5. 5Ultrafast time measurements by time-correlated single photon counting coupled with superconducting single photon detector2016 · 81 citations