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August 15, 2025NeurophotonicsOpen Access

Quantitative analysis of lipofuscin in neurodegenerative diseases using serial sectioning two-photon microscopy and fluorescence lifetime imaging microscopy

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Authors

AAAyman AbdelhakeemSCShuaibin ChangANAnna Novoseltseva

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Overview

Analysis reveals distinct lipofuscin patterns in Alzheimer's disease and other neurodegenerative diseases, indicating potential biomarkers.

Key Points

  • Lipofuscin accumulation differs significantly between Alzheimer's disease and control samples in gray matter regions.
  • Quantitative metrics showed distinct spatial patterns of lipofuscin across different brain regions, especially in late-stage cases.
  • The method utilized two-photon microscopy and fluorescence lifetime imaging for accurate analysis of lipofuscin aggregates.
  • Findings suggest a potential pathological role for lipofuscin in neurodegenerative diseases, particularly in the context of cell distribution.

Cite This Study

Abdelhakeem et al. (2025) studied this question.

synapsesocial.com/papers/68a365600a429f797332b573https://doi.org/10.1117/1.nph.12.3.035007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis.2026
  2. 2Interrogation of retinal lipofuscin by fluorescence lifetime imaging microscopy2025
  3. 3Cellular accumulation of lipofuscin in the heart: implications in health and disease2026
  4. 4Towards periodic whole-body lipofuscin removal2024
  5. 5Lipofuscin Accumulation in Rat Hippocampal Neurons as a Marker of Oxidative Stress Induced by Extreme Hyperoxia2026