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June 27, 2026Histochemistry and Cell BiologyOpen Access

Cellular accumulation of lipofuscin in the heart: implications in health and disease

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Authors

ALAmy LiSLSean LalGSGerald J. Shami

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Overview

Review examines lipofuscin formation and its impacts on heart aging and disease mechanisms.

Key Points

  • This paper explores the formation of lipofuscin and its implications for aging and heart diseases.
  • Review of existing literature on lipofuscin in heart cells and their morphological characteristics.
  • Discussion on the identification techniques like histopathology and transmission electron microscopy.
  • Lipofuscin presence is primarily noted in cardiomyocytes due to their limited proliferative capacity.
  • Understanding lipofuscin's role reveals potential links to heart-related aging and disease mechanisms.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a3f68f5aea7db3c1953fe8ahttps://doi.org/10.1007/s00418-026-02501-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From lipofuscin accumulation to cellular dysfunction: a focus on liver pathophysiology2026
  2. 2Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death2024 · 1 citations
  3. 3Lipid Inclusions in Cardiac Myocytes – a Rare Case of Cardiolipotoxicity2020 · 3 citations
  4. 4Electron microscopic observations on lysosomes and related cytoplasmic components of normal and pathological cardiac muscle1965 · 56 citations
  5. 5The Senescent Heart—“Age Doth Wither Its Infinite Variety”2024 · 9 citations