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June 27, 2026Histochemistry and Cell BiologyOpen Access

From lipofuscin accumulation to cellular dysfunction: a focus on liver pathophysiology

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Authors

FBFilip BraetEWEddie WisseGKGer H. Koek

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Overview

Review highlights lipofuscin's effects on liver health, indicating its role in cellular dysfunction due to stress.

Key Points

  • This review aims to summarize the knowledge regarding lipofuscin accumulation and its role in liver pathophysiology.
  • Literature review on cellular pigments in liver tissue
  • Analysis of lipofuscin's biochemical composition and cellular implications
  • Discussion of histological staining techniques for diagnosis
  • Lipofuscin accumulation is linked to oxidative damage and impaired detoxification in the liver.
  • Typical histological stains reveal characteristic irregular intracellular inclusions that are notable in liver tissue.
  • Liver parenchymal cells show susceptibility to aging despite efficient waste disposal mechanisms.

Cite This Study

Braet et al. (2026) studied this question.

synapsesocial.com/papers/6a3f69caaea7db3c195408aahttps://doi.org/10.1007/s00418-026-02502-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular accumulation of lipofuscin in the heart: implications in health and disease2026
  2. 2Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death2024 · 1 citations
  3. 3Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis.2026
  4. 4MITOCHONDRIAL LIPID PEROXIDATION INITIATES RAPID ACCUMULATION OF LIPOFUSCIN IN CELL CULTURE2025
  5. 5Photooxidation Dynamics of Lipofuscin in the Presence of Carotenoid-Binding Protein AstaP: Fluorescence Lifetime Imaging and Pigment Composition Analysis2026 · 2 citations