Detailed molecular investigation of Marek’s disease virus circulating in organised poultry farms in India revealed emergence of highly virulent MDV causing varied tissue tropism

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Emergence of virulent mdv strains indicated significant tissue tropism, particularly affecting the brain.
Infection involved 179 birds with gross tumours, all PCR-positive for the mdv genome, revealing widespread virulence.
Molecular characterisation through phylogenetic analysis of the meq gene showed critical amino acid substitutions linked to virulence.
Findings highlight the urgent need for enhanced surveillance and revised vaccination strategies in poultry farms.

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Analysis reveals emergence of virulent mdv strains with significant tissue tropism in birds, suggesting new challenges for vaccination strategies.

Mariappan et al. (2025) studied this question.

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Analysis reveals emergence of virulent mdv strains with significant tissue tropism in birds, suggesting new challenges for vaccination strategies.