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September 18, 2025Critical Care Medicine

Early Enteral Nutrition and Clinical Outcomes in Critically Ill Pediatric Populations: A Systematic Review and Meta-Analysis

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Authors

NGNicole GilbertAlberta Health ServicesESEmma SchalmUniversity of CalgaryKWKrista WollnyAlberta Health Services

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Implication

Systematic review shows early enteral nutrition may decrease mortality in critically ill children, suggesting beneficial clinical outcomes.

Key Points

  • Receiving early enteral nutrition was linked to reduced mortality in critically ill children, pointing to potential benefits.
  • In adjusted analyses, the odds ratio for reduced mortality with early enteral nutrition was 0.36, indicating significant clinical implications.
  • This systematic review included 18 studies, combining evidence from randomized control trials and cohort studies for comprehensive insights.
  • Limited confounding adjustment and study heterogeneity suggest caution in interpreting findings, highlighting the need for further research.

Cite This Study

Gilbert et al. (2025) studied this question.

synapsesocial.com/papers/68d461cb31b076d99fa611b7https://doi.org/10.1097/ccm.0000000000006859
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nutritional practices and their relationship to clinical outcomes in critically ill children—An international multicenter cohort study*2012 · 478 citations
  2. 2THE 2002 CLINICAL RESEARCH AWARD2002 · 100 citations
  3. 3The PRISMA 2020 statement: an updated guideline for reporting systematic reviews2021 · 107,295 citations
  4. 4Impact of Early Enteral Nutrition on the Hospital Stay of Pediatric Patients Undergoing Mechanical Ventilation2022 · 5 citations