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September 18, 2025Science AdvancesOpen Access

Cell-extrinsic controls over neocortical neuron fate and diversity

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Authors

NBNatalia BaumannIMIlaria MorassutSRSergi Roig‐Puiggros

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Overview

This research examines cellular diversity changes in neocortical neurons, highlighting cell-extrinsic interactions during development.

Key Points

  • Neocortical neuron identity shapes through specific conditions that vary between in vivo and in vitro environments.
  • In vivo models maintained cell identity while in vitro glutamatergic neurons showed reduced diversity and altered connectivity.
  • Cell class features emerged first in development, followed by subclass-related characteristics in an observed hierarchy.
  • Organotypic cultures yielded cellular identity and diversity values closest to in vivo conditions, indicating environmental influences.

Cite This Study

Baumann et al. (2025) studied this question.

synapsesocial.com/papers/68d461d231b076d99fa61503https://doi.org/10.1126/sciadv.adw0218
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