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September 18, 2025Scientific ReportsOpen Access

Differential effects of hemodialysis modalities on circulating neutrophil extracellular traps in children on maintenance hemodialysis: a cohort study

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Cohort study reveals reduced neutrophil extracellular traps levels in children during hemodialysis, suggesting benefits of OL-HDF over HFHD.

Children on hemodialysis show significantly elevated levels of circulating neutrophil extracellular traps, implying an inflammatory response.
Post-session levels of neutrophil extracellular traps were significantly reduced by both HFHD and OL-HDF compared to pre-session levels.
Hemodialysis via LFHD resulted in elevated neutrophil counts, highlighting potential risks associated with conventional dialysis methods.
The study indicates that OL-HDF is superior to HFHD in reducing neutrophil activation and inflammation in pediatric patients.

Kasem et al. (2025) studied this question.

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Cohort study reveals reduced neutrophil extracellular traps levels in children during hemodialysis, suggesting benefits of OL-HDF over HFHD.