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September 18, 2025

Prevalence and factors associated with Haematological side effects in MDR/RR-TB Patients on Linezolid-Based Regimens in Uganda: A Multicentre Retrospective Study

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Authors

EAEsther ApioJBJoseph Baruch BalukuDBDenis Bwayo

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Overview

Retrospective study reveals high prevalence of haematological toxicity in MDR/RR-TB patients, suggesting targeted monitoring is needed.

Key Points

  • 62.9% of patients experienced at least one haematological side effect after starting linezolid treatment.
  • Thrombocytopenia and leukopenia were the most prevalent, affecting over half of the patients.
  • Independent risk factors included rural residence, divorced/widowed status, and smoking habits.
  • Despite high toxicity rates, 86% of patients successfully completed treatment, though follow-up loss was notably higher among affected patients.

Cite This Study

Apio et al. (2025) studied this question.

synapsesocial.com/papers/68d462c131b076d99fa61ed7https://doi.org/10.21203/rs.3.rs-7220294/v1
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