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June 20, 2026Annals of the National Academy of Medical Sciences (India)Open Access

Profiling adverse reactions to novel drug-resistant tuberculosis regimens containing bedaquiline and linezolid

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Authors

RDRamakant DixitPMPrakhar MaheshwariAGAnkur Gupta

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Overview

Prospective observational study evaluates adverse drug reactions in drug-resistant TB patients, highlighting key management strategies.

Key Points

  • This study aims to evaluate adverse drug reactions in patients with drug-resistant tuberculosis to enhance treatment outcomes.
  • Prospective observational descriptive study involving 145 registered DR-TB patients over two years.
  • Collected demographic, clinical, and treatment data from patients who developed adverse drug reactions.
  • Assessed adverse drug reactions using statistical methods to explore associations with various patient factors.
  • ADRs occurred in 54.5% of DR-TB patients, with peripheral neuropathy being the most common at 41.3%.
  • Linezolid was responsible for 58.6% of all reported ADRs.
  • No significant associations were found between ADRs and factors like age, sex, or HIV status.

Cite This Study

Dixit et al. (2026) studied this question.

synapsesocial.com/papers/6a3630f5db0793dc1a537f46https://doi.org/10.25259/anams_257_2025
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Also Consider

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  1. 1High cure rate with standardised short-course multidrug-resistant tuberculosis treatment in Niger: no relapses2014 · 228 citations
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  4. 4Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis2012 · 420 citations
  5. 5Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis2022 · 12 citations