What question did this study set out to answer?

To evaluate the incidence and severity of adverse drug reactions in patients receiving longer all-oral MDR/XDR-TB regimens under the National TB Elimination Program.

July 15, 2026Annals of PharmacotherapyOpen Access

Adverse Drug Reactions Associated With Longer All-Oral MDR/XDR-TB Regimens: Prospective Pharmacovigilance Evidence From a High-Burden Tertiary Care Setting in North India

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Authors

AKAmit KambojDelhi Pharmaceutical Science and Research University KAK N AgarwalGuru Teg Bahadur Hospital RRRekha RaoGuru Jambheshwar University of Science and Technology

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Implication

Prospective cohort study evaluates adverse reactions in patients on all-oral MDR/XDR-TB regimens, showing mostly mild effects and high treatment success.

Key Points

To evaluate the incidence and severity of adverse drug reactions in patients receiving longer all-oral MDR/XDR-TB regimens under the National TB Elimination Program.
Prospective cohort study of MDR/XDR-TB patients starting all-oral therapy from March 2023 to September 2023.
Active monitoring of adverse drug reactions via structured interviews and clinical assessments.
Treatment outcomes classified per WHO definitions.
102 out of 143 registered patients enrolled, with 79 achieving favourable outcomes (77.5%).
158 adverse drug reactions reported, predominantly mild (81.0% classified as Hartwig levels 1-2).
Significant ADRs included linezolid-related haematological toxicity and peripheral neuropathy; no severe ADRs or deaths were observed.

Cite This Study

Kamboj et al. (2026) studied this question.

synapsesocial.com/papers/6a57248e88b21df875480dc6 https://doi.org/10.1177/10600280261458738

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Implication

Prospective cohort study evaluates adverse reactions in patients on all-oral MDR/XDR-TB regimens, showing mostly mild effects and high treatment success.

Adverse Drug Reactions Associated With Longer All-Oral MDR/XDR-TB Regimens: Prospective Pharmacovigilance Evidence From a High-Burden Tertiary Care Setting in North India

Discussion

Member takes

Implication

Key Points

Cite This Study

Adverse Drug Reactions Associated With Longer All-Oral MDR/XDR-TB Regimens: Prospective Pharmacovigilance Evidence From a High-Burden Tertiary Care Setting in North India

Discussion

Member takes

Implication

Key Points

Cite This Study

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