The Application of Trifluoroacetic Acid in the Minisci Silylation of Heteroarenes

A photoinduced Minisci reaction involving Si-H bond activation via a CF3 radical generated from trifluoroacetic acid as a hydrogen atom transfer reagent has been achieved for the first time. This approach enables the synthesis of a diverse array of silylated electron-deficient heteroarenes in moderate to high yields. Mechanistic studies were conducted to provide supporting evidence for the reaction process. The reaction features a metal-free protocol, operational simplicity, and compatibility with mild reaction conditions.