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September 18, 2025Open Access

Cell-cycle dynamics of nascent transcription and mature RNA accumulation are concordant in normal fibroblasts

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Authors

MGMelanie E. GucwaKIKohta Ikegami

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Overview

Analysis reveals that nascent transcription and RNA accumulation are concordant in human fibroblasts, suggesting implications for transcriptional regulation.

Key Points

  • The study shows that nascent transcription and mature RNA accumulation are highly concordant in normal fibroblasts.
  • Data indicate there is no significant lag between transcription and RNA accumulation during the cell cycle phases.
  • Co-profiling of nascent transcription and mature RNAs was performed in cycling human fibroblasts, highlighting cellular behavior.
  • These findings challenge the existing model of temporal segregation of transcriptional regulation and RNA abundance in human cells.

Cite This Study

Gucwa et al. (2025) studied this question.

synapsesocial.com/papers/68d462ca31b076d99fa622bchttps://doi.org/10.1101/2025.09.12.675830
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