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September 18, 2025Frontiers in ImmunologyOpen Access

Immunotherapy strategies targeting tumor-associated macrophages and their mechanisms of action in tumor progression

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Authors

HZHaixia ZhuJSJingjing ShaoLSLili Shao

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Overview

This review highlights the mechanisms of action of tumor-associated macrophages in tumor progression, suggesting new immunotherapy targets.

Key Points

  • Tumor-associated macrophages play a crucial role in regulating tumor progression and immune responses.
  • Recent advancements in single-cell sequencing have illuminated the diverse functionalities of tumor-associated macrophages.
  • Targeting tumor-associated macrophages opens new avenues for effective immunotherapy strategies against solid tumors.
  • The interaction between tumor-associated macrophages and tumor cells significantly impacts tumor microenvironment dynamics.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68d462d231b076d99fa625b6https://doi.org/10.3389/fimmu.2025.1680455
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