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September 18, 2025Archives of Gynecology and ObstetricsOpen Access

Reductive stress and the role of antioxidants in male infertility: a narrative review

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Authors

EMEfthalia MoustakliUniversity of IoanninaPCPanagiotis ChristopoulosNational and Kapodistrian University of AthensAPAnastasios PotirisNational and Kapodistrian University of Athens

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Implication

Narrative review examines how excessive antioxidants can cause reductive stress, impacting sperm quality and male infertility.

Key Points

  • Excessive antioxidants may lead to reductive stress, negatively affecting sperm function and quality.
  • Reductive stress impairs cellular signaling and mitochondrial integrity, posing risks to male reproductive health.
  • Clinical guidelines are lacking for monitoring redox equilibrium during antioxidant therapy for infertility.
  • A balanced approach to antioxidant use is needed to ensure redox homeostasis and avoid potential harms.

Cite This Study

Moustakli et al. (2025) studied this question.

synapsesocial.com/papers/68d462d231b076d99fa62712https://doi.org/10.1007/s00404-025-08184-3
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